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Inhibition of PDE5 by Tadalafil increases the concentrations of cGMP resulting in relaxation of pulmonary vascular smooth muscle cells and erection of the pulmonary vascular bed. Studies in vitro have demonstrated that Tadalafil is a selective inhibitor of PDE5. PDE5 is found in pulmonary vascular smooth muscle, visceral smooth muscle, corpus cavernosum, skeletal muscle, platelets, kidney, lung, cerebellum, and pancreas.

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Can women use tadalafil. Women can use tadalafil for pulmonary hypertension.

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These factors may affect how you should use this medication. Alcohol: Consumption of alcohol may decrease the ability to achieve an erection and may also temporarily decrease blood pressure, causing dizziness and fainting.